Lignans and Melatonin Blend for Dogs


Lignans and Melatonin Blend for Dogs

Lignans and Melatonin Blend for Dogs has a rating of 4.5 stars based on 81 reviews.

Unique blend of lignans and melatonin

May help nervous or high-strung dogs

Research shows lowered cortisol levels in dogs with Cushing's


Dogs up to 25 lb Dogs over 25 lb


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  • Description
  • Ingredients
  • Directions
  • FAQs
  • Certifications
  • Research
Lignans and Melatonin Blend for Dogs

Nature's Remedy

Lignans and Melatonin Blend is a unique combination of SDG lignans with the added benefit of melatonin in one tablet. It comes in two sizes, based on your dog's weight.

Melatonin for Dogs

Melatonin is a natural hormone produced by the pineal gland. Its primary role is to regulate the sleep-wake cycle and maintain hormonal balance within the body. Properly administered, it’s a gentle, effective natural remedy and carries no risk of side effects. Melatonin is a natural calming aid, and is great for high-strung or nervous dogs. This natural hormone may help with hyperactivity, restlessness, and separation issues. The calming qualities in melatonin are also useful for stressful situations like 4th of July fireworks or other loud noises that cause dogs stress. 

By supplementing their natural melatonin levels, dogs can experience improved sleep quality which benefits their overall wellbeing. And a rested dog equals a rested dog parent, too! Gone are the nights of waking up at all hours to a restless, sleepless pooch!

It's this same quality that makes melatonin a great addition to help treat Cushing's disease symptoms. If you’ve studied Cushing’s disease, you know that it causes the dog’s body to produce excessive amounts of cortisol (a stress hormone) which has numerous side effects like high blood pressure. Studies conducted at the University of Tennessee confirmed that melatonin can help reduce excess cortisol levels and for this reason melatonin is an excellent option to help with adrenal issues like Cushing’s Disease. Without the use of melatonin, lignans are not as effective in treating Cushing's on their own.

Your Pet Deserves It

Lignans - A Natural Choice for Cushing’s

Flaxseed is one of the world’s oldest cultivated crops, having been grown since the dawn of human civilization. The Latin name of the flaxseed plant is Linum usitatissimum, meaning “very useful.” In addition to food and fiber, flaxseeds also offer medicinal properties to dogs with Cushing’s. Like Melatonin, SDG lignans extracted from flaxseed have been studied for their ability to help lower excessive cortisol levels. Research shows that combining flaxseed lignans with melatonin serves to lower cortisol levels*, rendering this combination particularly useful for dogs with Cushing’s.  


Jack W. Oliver, DVM, Ph.D Knoxville, TN 

Melatonin for Dogs is used in holistic and veterinary medicine along with Lignans as a natural treatment for Cushing's. Studies show reduced cortisol in dogs when given as a combination. 

The Lignans and Melatonin Blend can be given safely with our Cushing's Killer Combo.

For Dogs up to 25 lb:

Active Ingredients per tablet:

Melatonin…1 mg

SDG Lignans (from Flaxseed Extract)...10 mg

Inactive Ingredients: Dicalcium Phosphate, Natural & Artificial Flavors, Salt, Silicon Dioxide, Sorbitol, Sucrose.

For Dogs over 25 lb:

Active Ingredients per tablet:

Melatonin…3 mg

SDG Lignans (from Flaxseed Extract)…20 mg

Inactive Ingredients: Dicalcium Phosphate, Natural & Artificial Flavors, Salt, Silicon Dioxide, Sorbitol, Sucrose.

For Dogs up to 25 lb:

Directions for use

  • Dogs up to 10 lb: 1 tablet per day
  • Dogs 10 - 25 lb: 1.5 tablets per day

For Dogs over 25 lb:

Directions for use:

  • Dogs 26 - 100 lb: 1 tablet per day
  • Dogs over 100 lb: 1.5 tablets per day

Use initially for at least one month. Store product at room temperature. Do not expose to excessive heat or moisture.


These are Frequently Asked Questions:

Q. Can this be administered alongside prescription medications such as Vetoryl?
A. The product should not interfere with any medications currently being administered. It is up to the customer if they would like to administer our product alongside other medications. Always speak to your vet about how to take your pet off prescription medications safely.

Q. How long does the bottle last?
A. A bottle will last varying amounts of time based on your dog's weight.

Q. Are there any side effects?
A. In most cases there are no serious side effects associated with this product. Always cross-check the ingredients with any pre-existing allergy your pet may have.

Q. How long before I see results?
A. You should see results within 3-4 weeks. If you are not satisfied we recommend taking advantage of our guarantee.


Q. What is your return policy?
A. We offer a 100% money-back guarantee for up to 365 days. If it's not helping send it back for a full product refund.

*These statements below have not been evaluated by Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information on this Web site or in emails is designed for educational purposes only. It is not intended to be a substitute for informed medical advice or care. Prana Pets bases these statements on the historically established and widely acknowledged traditional uses of natural ingredients.